منابع مشابه
Quantification of miRNA-mRNA Interactions
miRNAs are small RNA molecules (' 22nt) that interact with their corresponding target mRNAs inhibiting the translation of the mRNA into proteins and cleaving the target mRNA. This second effect diminishes the overall expression of the target mRNA. Several miRNA-mRNA relationship databases have been deployed, most of them based on sequence complementarities. However, the number of false positive...
متن کاملIntegrative Analysis of miRNA-mRNA and miRNA-miRNA Interactions
MicroRNAs (miRNAs) are small, noncoding regulatory molecules. They are involved in many essential biological processes and act by suppressing gene expression. The present work reports an integrative analysis of miRNA-mRNA and miRNA-miRNA interactions and their regulatory patterns using high-throughput miRNA and mRNA datasets. Aberrantly expressed miRNA and mRNA profiles were obtained based on f...
متن کاملHierarchical and Overlapping Co-Clustering of mRNA: miRNA Interactions
microRNAs (miRNAs) are an important class of regulatory factors controlling gene expressions at post-transcriptional level. Studies on interactions between different miRNAs and their target genes are of utmost importance to understand the role of miRNAs in the control of biological processes. This paper contributes to these studies by proposing a method for the extraction of co-clusters of miRN...
متن کاملBayesian Analysis for miRNA and mRNA Interactions Using Expression Data
MicroRNAs (miRNAs) are small RNA molecules composed of 19–22 nt, which play important regulatory roles in post-transcriptional gene regulation by inhibiting the translation of the mRNA into proteins or otherwise cleaving the target mRNA. Inferring miRNA targets provides useful information for understanding the roles of miRNA in biological processes that are potentially involved in complex disea...
متن کاملExploring conserved mRNA-miRNA interactions in colon and lung cancers
Aim The main goal of this analysis was prioritization of co-expressed genes and miRNAs that are thought to have important influences in the pathogenesis of colon and lung cancers. Background MicroRNAs (miRNAs) as small and endogenous noncoding RNAs which regulate gene expression by repressing mRNA translation or decreasing stability of mRNAs; they have proven pivotal roles in different types ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0030766